Monday, October 18, 2010

Protein Data Bank

PROTEIN DATA BANK (PDB)

Protein Data Bank (PDB) is a repository for 3-D biological macromolecular structure such as proteins and nucleic acid. The data, typically obtained by X-ray crystallography or NMR spectroscopy and submitted by biologists and biochemists from around the world, are freely accessible on the internet. The PDB is overseen by an organization called the Worldwide Protein Data Bank, wwPDB. The PDB database is updated weekly every Tuesday. Up until 21 September 2010, there are 68421 structures that exist in the PDB. Table below show the experimental method to show the structures.

Experimental
Method
Proteins Nucleic Acids Protein/Nucleic Acid
complexes
Other Total
X-ray diffraction 55480 1231 2605 17 59333
NMR 7512 925 162 7 8606
Electron microscopy 214 17 77 0 308
Hybrid 24 1 1 1 27
Other 126 4 4 13 147
Total: 63356 2178 2849 38 68421

One example that we can take from the Pdb database is the structure of LexA protein. We can search for it in the search box at the top of the page as shown below.






Next, we click at the first type of LexA proteins that come out in the search. Here we can see the description of the LexA protein with it scientific name.


We also can download the structure from this page and by using Raswin, we can alter the colour and shape of the structures. For example, below I use the stick for display and group for colour.

There are other type of display and colour that we can choose by using Raswin. Anybody who would like to download this program can click here

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